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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1
All Species:
10
Human Site:
Y423
Identified Species:
22
UniProt:
O15118
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15118
NP_000262.2
1278
142167
Y423
D
K
H
I
Y
Q
P
Y
P
S
G
A
D
V
P
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
Y423
D
K
H
T
Y
Q
P
Y
P
S
G
A
D
V
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O35604
1278
142870
Y424
S
V
H
I
Y
E
P
Y
P
A
G
A
D
V
P
Rat
Rattus norvegicus
Q6T3U3
1331
146397
L425
S
S
Y
K
Y
D
S
L
L
L
G
S
K
N
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419162
1261
140678
P417
G
A
D
V
P
F
G
P
P
L
N
K
D
I
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919958
1164
130467
N368
P
L
S
P
Y
N
D
N
C
T
I
L
S
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609357
1287
143273
S426
P
Q
I
V
H
N
T
S
N
G
P
Y
T
F
G
Honey Bee
Apis mellifera
XP_624752
1358
152373
F424
Q
I
T
F
G
P
V
F
N
D
T
F
L
K
T
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
Y426
F
Q
S
S
G
K
L
Y
G
P
V
F
H
K
D
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
Q459
K
P
Y
N
V
T
R
Q
Y
P
S
E
A
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
N374
I
N
L
W
V
S
K
N
S
E
K
F
K
E
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
N.A.
N.A.
N.A.
86.2
39.1
N.A.
N.A.
78
N.A.
63.8
N.A.
45.1
43
28
49.1
Protein Similarity:
100
99.4
N.A.
N.A.
N.A.
93.3
58.3
N.A.
N.A.
87.7
N.A.
76
N.A.
63.2
60.9
47.7
65.5
P-Site Identity:
100
93.3
N.A.
N.A.
N.A.
73.3
13.3
N.A.
N.A.
13.3
N.A.
13.3
N.A.
0
0
6.6
0
P-Site Similarity:
100
93.3
N.A.
N.A.
N.A.
86.6
26.6
N.A.
N.A.
26.6
N.A.
20
N.A.
20
6.6
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
10
0
28
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
19
0
10
0
0
10
10
0
0
10
0
0
37
0
10
% D
% Glu:
0
0
0
0
0
10
0
0
0
10
0
10
0
10
0
% E
% Phe:
10
0
0
10
0
10
0
10
0
0
0
28
0
10
10
% F
% Gly:
10
0
0
0
19
0
10
0
10
10
37
0
0
0
10
% G
% His:
0
0
28
0
10
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
10
10
10
19
0
0
0
0
0
0
10
0
0
10
0
% I
% Lys:
10
19
0
10
0
10
10
0
0
0
10
10
19
19
10
% K
% Leu:
0
10
10
0
0
0
10
10
10
19
0
10
10
0
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
10
0
19
0
19
19
0
10
0
0
10
0
% N
% Pro:
19
10
0
10
10
10
28
10
37
19
10
0
0
0
28
% P
% Gln:
10
19
0
0
0
19
0
10
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% R
% Ser:
19
10
19
10
0
10
10
10
10
19
10
10
10
0
0
% S
% Thr:
0
0
10
10
0
10
10
0
0
10
10
0
10
10
19
% T
% Val:
0
10
0
19
19
0
10
0
0
0
10
0
0
37
0
% V
% Trp:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
19
0
46
0
0
37
10
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _